Imaging Probe Development Center (IPDC)

Scope of the IPDC

The IPDC will consider for preparation all classes of molecular imaging probes along with their precursors, encompassing all imaging modalities. We particularly work on fluorescent, magnetic resonance and radiolabeled detectable moieties, often bound to selective or specific tissue targeting agents. Chemical compositions can range from all classes of low molecular weight drug-like molecules, natural products and their analogs, peptides along with peptidomimetics and unnatural peptides, carbohydrates, nucleotides and oligonucleotides and their analogs, radioisotopes, metals and radiometals, multifunctional chelating agents, polymers such as dendrimers and poly(ethylene)glycols, proteins such as antibodies, fragments and toxins, and particulates such as nanoparticles and microparticles.

Principal Investigators (NIH Institute/Center) and Titles of IPDC Projects
June 2009

Balaban, Robert (NHLBI)

• A Decolorized Analog of Coomassie Brilliant Blue for Electrophoreses

Baron, Gerald (NIAID)

• Fluorescent Probes to Image Prion Protein Trafficking

Braun, Allen (NIDCD)

• Thyroid Hormone actions in CNS studied with I-124 PET

Bugge, Thomas (NIDCR) and Leppla, Stephen (NIAID)

• Protease Imaging Agents

Capala, Jacek (NCI)

• Affibody-Based Molecular Imaging probes for In Vivo Characterization of Growth Factor Expression

Chock, Boon P. (NHLBI)

• Synthesis of a Sensitive Fluorogenic Substrate for Phospholipase C

Choyke, Peter L. (NCI)

• Gadolinium Labeled PAMAM Dendrimers for Vascular Imaging

Clore, G. Marius (NIDDK)

• Synthesis of the CLaNP-5 caged lanthanide NMR probe for paramagnetic relaxation enhancement studies on the structure and dynamics of biological macromolecules and their complexes

Diamond, Jeffrey (NINDS)

• Caged mGluR antagonist for rapid activation of ON bipolar cells in retina

Doroshow, James H. (NCI)

• ApoSense Imaging Probe Development

Doroshow, James H. (NCI)

• Lapatinib Imaging Probe Development

Dyall, Julie, Jennings, Jerry, Chen, Dar-Yeong, Paragas, Jason, Jahrling, Peter (NIAID)

• Development of Radiolabeled Substrates of HSV-1 Thymidine Kinase for In Vivo Molecular Imaging of Infectious Diseases

Dyall, Julie, (NIAID)

• In vivo Molecular Imaging of Ebola virus Infection

Fessler, Michael B. (NIEHS)

• Synthesis of fPEG-cholesterol Conjugates

Freed, E. (NCI)

• Fluorescent Analogs of Amphotericin B methyl Ester

Galbraith, Catherine (NIDCR)

• Synthesis of Caged Q-Rhodamine and Fluorescein Conjugated to Antibody 9EG7

Gandjbakhche, Amir (NICHD)

• Modulation of Fluorescence Lifetime with Metal Chelates

Gershengorn, Marvin (NIDDK)

• Imaging Probes for the Human TSH Receptor

Gottesman, Michael and Calcagno, Anna (NCI)

• ABCG2-Specific Imaging Agents for Breast Cancer

Grimes, Amy (NHLBI)

• Proposed Synthesis of a Fluorescent Dansyl-Kainate Analog

Hall, Matthew D. (NCI)

• Synthesis of Fluorescent Derivatives of NSC73306

Hassan, Moinuddin (NICHD)

• Activated Cypher Dyes for Protein Conjugation and Conjugate Testing

Hawkins, Mary E. (NCI)

• Syntheses of Pteridine Nucleotides as RNA Probes

Isaac, John (NINDS)

• Caged AMPA Receptor Ligands for Use with Two-Photon Excitation

Jacobson, Kenneth (NIDDK)

• Radioligands for in vivo Imaging of A3 Adenosine Receptors

Klein, David C. (NICHD)

• Dopamine 4 Receptors

Knutson, Jay (NHLBI)

• Design and Synthesis of Luminescent Probes suitable for use in Nonlinear Optical and Superresolution Microscopy (STED, STAQ and beyond)

Krensky, Alan and Clayberger Carol (NCI)

• Granulysin

Krishna, Murali (NCI)

• Nitroxide Radical Probes as Redox-sensitive MRI Contrast Agents for Assessment of Radiation-Induced Damage, Neuropathological Diseases, and Inflammation

LeGrice, Stuart F. J. (NCI)

• Synthesis of the Trifunctional Agent NBzM

Lippincott-Schwartz, Jennifer (NICHD)

• Synthesis of Caged Fluorescent Molecules

Newman, Amy (NIDA)

• D3 Receptor Imaging Agents

Park, John (NINDS)

• Synthesis of Fluorescently Labeled and Sulfhydryl-Modified pH Sensitive Polymers for Development as siRNA Delivery Agents

Potter, Kimberlee (U.S. Army)

• Development of Novel Manganese Chelates for Studying Mineralization

Qasba, Pradman (NCI)

• Proposal for the Synthesis of UDP2ketoGal from the Imaging Probe Development Center

Rein, Alan (NCI)

• Biarsenical Compounds for Site-Specific Labeling of Protein Tetracysteine Motifs

Roney, Celeste (CC)

• Targeted Oral Contrast Development for Colonic Polyp Detection on Computed Tomography

Rubin, Jeffrey (NCI)

• 125I-Radiolabeling of Secreted Frizzled-Related Protein-1

Sarin, Hemant (NIBIB/CC)

• Gd-Dendrimer Reagents for Preclinical Studies of Glioma Using MRI

Sarraf, Pasha (NIAMS)

• Proposal for Imaging of SAA Amyloidosis

Soldatov, Nikolai (NIA)

• Cy3 Fluorescent Derivative of Gabapentine as a New Tool of Calcium Channel Research with Potential Application in Anthrax Study

Subramaniam, Sriram (NCI)

• Construction of Gold-based Imaging Probes for Mapping Drug Binding Sites on HIV-1 Envelope Glycoproteins

Ungerleider, Leslie G. (NIMH)

• MR Imaging Probes Development for Brain Neural Circuitry Study

Tootell, Roger & Ungerleider, Leslie (NIMH)

• SPIO MRI Agents

Wierzchoslawski, Rafal (NCI)

• Fluorescence Labeled Nucleotides as Probes for in vivo Detection of HIV-1 Preintegration Complexes

Young, W. Scott (NIMH)

• Radiolabeled Ligands for the Vasopressin 1 b Receptor for in vitro Receptor Autoradiographic Studies

Zheng, Wei (NHGRI)

• Development of Fluorogenic Substrates of Alpha-Glucosidase, Alpha-Galactosidase and Glucocerebrosidase for Research on Pompe, Fabry and Gaucher Diseases

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