• Roadmap Home
• Roadmap Initiatives
• Funding Opportunities
• Funded Research
• FAQs
• Science News

High-Risk Research

Overview Implementation Group Members Funding Opportunities Funded Research NIH Director’s Pioneer Award NIH Director’s New Innovator Award Transformative R01 Program

Funded Research Roadmap Transformative R01 Program (R01) RFA-RM 08-029 PI Name Institution Name Title AUSUBEL, FREDERICK M MASSACHUSETTS GENERAL HOSPITAL Identifying novel anti-infectives by high through-put screening in whole animals BRETON, SYLVIE MASSACHUSETTS GENERAL HOSPITAL 3-Dimensional modeling of basal cell function in pseudostratified epithelia CAMARERO, JULIO A UNIVERSITY OF SOUTHERN CALIFORNIA Cell-based screening and selection of cyclotide-based capture reagents for protein profiling using micro-array format COHEN, PINCHAS UNIVERSITY OF CALIFORNIA LOS ANGELES Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease CRAVATT, BENJAMIN F. (contact); KODADEK, THOMAS J SCRIPPS RESEARCH INSTITUTE Massively Parallel Identification of Protein Ligands CZECH, MICHAEL P UNIV OF MASSACHUSETTS MED SCH WORCESTER Oral Delivery Vehicles for RNAi Therapies DANUSER, GAUDENZ (contact); HAHN, KLAUS MICHAEL SCRIPPS RESEARCH INSTITUTE Quantitative Imaging of Signaling Networks DUBNAU, JOSHUA T COLD SPRING HARBOR LABORATORY Genome-wide regulatory network governing neuronal mRNA translation. FIDOCK, DAVID ARMAND COLUMBIA UNIVERSITY HEALTH SCIENCES Exploiting Fatty Acid Metabolism To Cure Malaria GRIFFITH, LINDA G. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems HOFFMAN, ANDREW R STANFORD UNIVERSITY Role of Long-Range Chromatin Interactions in Genetic Disease IYENGAR, SRINIVAS RAVI V (contact); HE, JOHN C HONE, JAMES C LOEW, LESLIE M NEVES, SUSANA R MOUNT SINAI SCHOOL OF MEDICINE OF NYU Dynamics Underlying Tissue Integrity JAFFREY, SAMIE R WEILL MEDICAL COLLEGE OF CORNELL UNIV Novel fluorescent sensors for simple, sensitive, and specific protein detection JI, RU-RONG (contact) SERHAN, CHARLES NICHOLAS BRIGHAM AND WOMEN'S HOSPITAL Resolvins, protectins, and chronic pain resolution KOIDE, SHOHEI UNIVERSITY OF CHICAGO Rational generation of directed protein-capture reagents KUO, CALVIN J STANFORD UNIVERSITY Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture LAGASSE, ERIC VA PALO ALTO HEALTH CARE SYSTEM Organogenesis of Ectopic Tissue in Lymph Node LEE, BRENDAN HL BAYLOR COLLEGE OF MEDICINE Argininosuccinate Lyase is an essential regulator of systemic nitric oxide production LEE, FRANK S UNIVERSITY OF PENNSYLVANIA The Hydroxylprolylproteome LEWIS, KIM NORTHEASTERN UNIVERSITY Super-persistent cells and the paradox of untreatable infections LI, LONG-CHENG (contact); LI, HAO UNIVERSITY OF CALIFORNIA SAN FRANCISCO Transcriptional Activation by Small RNA: Mechanism and Design Rules LIS, JOHN T (contact); CRAIGHEAD, HAROLD G JIN, MOONSOO M CORNELL UNIVERSITY Development of High Throughput Aptamer-based Protein Capture/Detection Assays towards Comprehensive Analysis of Human Proteome MACIEJEWSKI, JAROSLAW P CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE Viral Pathogenesis of Idiopathic Bone Marrow Failure and Immune Cytopenias MARGOLIS, PETER ADAM (contact); SEID, MICHAEL CHILDREN'S HOSPITAL MEDICAL CTR (CINCINNATI) Open Source Science: Transforming Chronic Illness Care MARKOVITZ, DAVID MICHAEL UNIVERSITY OF MICHIGAN AT ANN ARBOR Replication of Human Endogenous Retroviruses in Modern Humans MARKOWITZ, SANFORD D CASE WESTERN RESERVE UNIVERSITY Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis MARSHALL, WALLACE UNIVERSITY OF CALIFORNIA SAN FRANCISCO Pattern formation & regeneration in a single cell MITRA, PARTHA PRATIM COLD SPRING HARBOR LABORATORY The Missing Circuit: The First Brainwide Connectivity Map for Mouse MURDOCK, DEBORAH G VANDERBILT UNIVERSITY MEDICAL CENTER Fatty acid signals as quorum sensing regulators of mitochondrial biogenesis MURPHY, SHEILA T. (contact); BAEZCONDE GARBANATI, LOURDES ALBERTINA BALL-ROKEACH, SANDRA HAILE, ROBERT WILLIAM UNIVERSITY SOUTHERN CALIFORNIA Transforming Cancer Knowledge, Attitudes and Behavior through Narrative NISWENDER, KEVIN D (contact); GALLI, AURELIO ANTONIO VANDERBILT UNIVERSITY Insulin regulation of monoamine signaling: pathway to obesity PARSONNET, JULIE STANFORD UNIVERSITY Childhood infection and prevention of obesity POLLACK, GERALD H UNIVERSITY OF WASHINGTON Unexpectedly Profound Role of Water in Biology and Medicine RICE, CHARLES M. (contact); BHATIA, SANGEETA N. ROCKEFELLER UNIVERSITY Modeling human hepatotropic infections in complex tissue organoids ROBERTS, RICHARD W (contact); SOH, HYONGSOK TOM UNIVERSITY SOUTHERN CALIFORNIA Polypeptide Design with Proteomic Scope via Microfluidic mRNA Display SUKI, BELA BOSTON UNIVERSITY Regulatory roles of variable mechanical stimuli in cell function TEWARI, MUNEESH FRED HUTCHINSON CANCER RESEARCH CENTER RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small WALENSKY, LOREN D DANA-FARBER CANCER INSTITUTE A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactome WILSON, ROBERT B UNIVERSITY OF PENNSYLVANIA Random shRNA Selection WU, JOSEPH C STANFORD UNIVERSITY Re-Education of the Immune System for hES Cell Tolerance XIE, XIAOLIANG SUNNEY HARVARD UNIVERSITY Imaging the Invisible with No Labels: A Major Opportunity in Biology and Medicine ZYLKA, MARK JOHN UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Harnessing ectonucleotidases to treat chronic pain 2009 NIH Director’s Pioneer Award Program (DP1) RFA-RM 09-001 PI Name Institution Name Title BENJAMIN, IVOR J UNIVERSITY OF UTAH Protein Misfolding Diseases and Oxido-Reductive Pathways CHAWLA, AJAY STANFORD UNIVERSITY Immune Triggers of Tissue Regeneration CHEN, CHANG-ZHENG STANFORD UNIVERSITY The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes CHEROUTRE, HILDE LA JOLLA INST FOR ALLERGY & IMMUNOLOGY Uncovering the Missing Link that Determines Susceptibility to Autoimmunity COVERT, MARKUS W STANFORD UNIVERSITY A Gene-Complete Computational Model of Yeast DESIMONE, JOSEPH M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Delivery of Biological Therapeutics: Using Engineered Particles and Novel Deliver EVANS, SYLVIA M UNIVERSITY OF CALIFORNIA SAN DIEGO Approaches to Cardiac Regeneration FETCHO, JOSEPH R. CORNELL UNIVERSITY ITHACA Global changes in synaptic strength and excitability during sleep and wakefulness HOLY, TIMOTHY E WASHINGTON UNIVERSITY WATCHING ACTION POTENTIALS IN INTACT NEURONAL CIRCUITS REYA, TANNISHTHA DUKE UNIVERSITY Imaging self-renewal and transformation in hematopoietic stem cells ROBINSON, GENE E UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System ROSENBERG, SUSAN M. BAYLOR COLLEGE OF MEDICINE Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes SAMSON, LEONA D MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing novel methods to measure DNA repair capacity in human populations SHAH, NIRAO M UNIVERSITY OF CALIFORNIA SAN FRANCISCO Dissecting the neural control of social attachment SHENOY, KRISHNA V STANFORD UNIVERSITY Toward an Animal Model of Freely Moving Human TISHKOFF, SARAH UNIVERSITY OF PENNSYLVANIA African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits TRAVIS, ALEXANDER J CORNELL UNIVERSITY ITHACA Nanoscale energy production for implantable medical devices ZHANG, JIN JOHNS HOPKINS UNIVERSITY Creating a Genetically Encodable Nano-Compass to Navigate in Molecular Networks 2009 NIH Director’s New Innovator Award Program (DP2) RFA-RM 09-003 PI Name Institution Name Title ALBERS, MARK W MASSACHUSETTS GENERAL HOSPITAL The Olfactory Neural Circuit as a systems Level Model of Neurodegenerative Disease ALMUTAIRI, ADAH UNIVERSITY OF CALIFORNIA SAN DIEGO Chemically Amplified Response Strategies For Medical Sciences; Concepts Borrowed ASHLEY, EUAN A STANFORD UNIVERSITY Nanoscale Approaches To Allelic Silencing In Myocardial Disease States BAGNAT, MICHEL DUKE UNIVERSITY Discovering New Regulators Of Cftr And Fluid Secretion In Zebrafish BALAZSI, GABOR UNIVERSITY OF TEXAS MD ANDERSON CAN CTR Connecting The Selection Of Noisy Gene Expression Deviants To Genetic Evolution BANERJEE, IPSITA UNIVERSITY OF PITTSBURGH AT PITTSBURGH Defining Mechanisms Controlling Stem Cell Fate During Differentiation BROWN, EDWARD BERNARD UNIVERSITY OF ROCHESTER Exploiting Collagen Organization To Predict And Prevent Tumor Metastasis CAMARGO, FERNANDO CHILDREN'S HOSPITAL BOSTON Analysis Of Stem Cell Dynamics And Differentiation By Cellular Barcoding CHRONIS, NIKOLAOS UNIVERSITY OF MICHIGAN AT ANN ARBOR A Biochip For Point-Of-Care Hiv/Aids Diagnosis In The Developing World COHEN THEODORE H BRIGHAM AND WOMEN'S HOSPITAL Prevalence, Risk Factors And Consequences Of Complex M. Tuberculosis Infections DERIEMER, KATHRYN UNIVERSITY OF CALIFORNIA DAVIS Transmission And Virulence Of Mycobacterium Tuberculosis DIAZ, ELVA D UNIVERSITY OF CALIFORNIA DAVIS Generation Of Tumor Stem Cell Lines For Directed Therapeutics Of Brain Cancer ENGLER, ADAM JEFFREY UNIVERSITY OF CALIFORNIA SAN DIEGO Smart' Materials To Engineer A More Complete Stem Cell Niche GRISHOK, ALLA COLUMBIA UNIVERSITY HEALTH SCIENCES Investigating The Potential Of Endogenous Rnai In Mediating Adaptation To Environ HALL, IRA M UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Extent, Origin, and Control of Structural Variation in Mammalian Genomes HEILSHORN, SARAH C STANFORD UNIVERSITY Engineering 3D In Vitro Niches To Reveal Fundamentals Of Cellular Biomechanics HUANG KERWYN CASEY STANFORD UNIVERSITY Engineering Of Cell Shape And Intracellular Organization JAIN, SANJAY JOHNS HOPKINS UNIVERSITY Novel Imaging Biomarkers To Address Fundamental Controversies In Tb Pathogenesis JANES, KEVIN A. UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein KEMP, MELISSA LAMBETH GEORGIA INSTITUTE OF TECHNOLOGY Redox Regulation Of Cellular Information Processing KREIMAN, GABRIEL CHILDREN'S HOSPITAL BOSTON Towards The Neuronal Correlates Of Visual Awareness KRISTICH, CHRISTOPHER J MEDICAL COLLEGE OF WISCONSIN Genetic Approaches To Protein-Protein Interactions Mediating Antibiotic Resistanc KURDISTANI, SIAVASH UNIVERSITY OF CALIFORNIA LOS ANGELES A Blueprint For Oncogenic Epigenetic Reprogramming KWATE, NAA OYO A COLUMBIA UNIVERSITY HEALTH SCIENCES Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the LEE, KIBUM RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK Combinatorial Approaches For Studying Multiple Cues Regulating Human Pluripotent LIM, DANIEL A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Chromatin-Based Cellular Memory In Neural Stem Cells LOMVARDAS, STAVROS UNIVERSITY OF CALIFORNIA SAN FRANCISCO Characterization Of The Role Of Cpa Methylation In Neuronal Plasticity MACHADO, ANDRE GUELMAN CLEVELAND CLINIC LERNER COL/MED-CWRU Deep Brain Stimulation Of The Ventral Anterior Limb Of The Internal Capsule For M MASOPUST, DAVID UNIVERSITY OF MINNESOTA TWIN CITIES Maximizing Cd8 T Cells For Protection MORA, JORGE RODRIGO MASSACHUSETTS GENERAL HOSPITAL Reassessing The Physiological Role Of Gut-Specific Lymphocyte Homing: Implication MUOTRI, ALYSSON R UNIVERSITY OF CALIFORNIA SAN DIEGO Modeling Autism With Human Pluripotent Cells NAGRATH, SUNITHA MASSACHUSETTS GENERAL HOSPITAL Engineering Sensitive Microfluidic Multiplex Technology For Isolating Circulating NANDA, VIKAS UNIV OF MED/DENT NJ-R W JOHNSON MED SCH Computational Design Of A Synthetic Extracellular Matrix ORDWAY, DIANE JOYCE COLORADO STATE UNIVERSITY-FORT COLLINS Immune Modulation By Highly Virulent Clinical Isolates Of M.Tuberculosis OZCAN, AYDOGAN UNIVERSITY OF CALIFORNIA LOS ANGELES Towards Mega-Throughput, Label-Free Genomics And Proteomics: Revolutionizing Micr PAYNE, CHRISTINE K GEORGIA INSTITUTE OF TECHNOLOGY Intracellular Delivery And Targeting Of Nanoparticles PENN, ANNA A STANFORD UNIVERSITY Fetal Brain Damage: A Placental Disorder PURDON, PATRICK L. MASSACHUSETTS GENERAL HOSPITAL A Neural Systems Approach To Monitoring And Drug-Delivery For General Anesthesia QIAN, SHU-BING CORNELL UNIVERSITY ITHACA Engineering Ubiquitin Ligases To Investigate Protein Aggregation And Neurodegener QIAN, WEI-JUN BATTELLE PACIFIC NORTHWEST LABORATORIES A Universal Multiplex Assay System for High-Throughput Clinical Applications REIJMERS, LEON TUFTS UNIVERSITY BOSTON Molecular Analysis of Functional Neural Circuits REINEKE, THERESA M VIRGINIA POLYTECHNIC INST AND ST UNIV Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery RINN, JOHN LOUIS BETH ISRAEL DEACONESS MEDICAL CENTER RNA and Chromatin Formation: From Discovery to Mechanism SABETI, PARDIS CHRISTINE HARVARD UNIVERSITY Host and Pathogen Evolution in Lassa Fever SAINT-GENIEZ, MAGALI SCHEPENS EYE RESEARCH INSTITUTE Bioengineering of Bruch's Membrane for the treatment of Age-related Macular Degen SHOU, WENYING FRED HUTCHINSON CANCER RESEARCH CENTER Cellular Cooperation and Cheating: an Experimental and Mathematical Analysis SONNENBURG, JUSTIN STANFORD UNIVERSITY Discovery of gut microbiota-targeted small molecules: new tools and therapeutics TAVAZOIE, SOHAIL F ROCKEFELLER UNIVERSITY The discovery of microRNAs that predict chemotherapeutic responsiveness of cancer TIMLIN, JERILYN SANDIA CORP-SANDIA NATIONAL LABORATORIES Multiplexed Measurements of Protein Dynamics and Interactions at Extreme Resoluti TSO, CHO-LEA UNIVERSITY OF CALIFORNIA LOS ANGELES Cellular Quiescence and Brain Tumor Stem Cells ULLIAN, ERIK M UNIVERSITY OF CALIFORNIA SAN FRANCISCO The Role Of Astrocytes In Plasticity And Disease VEZYS, VAIVA D UNIVERSITY OF MINNESOTA TWIN CITIES Understanding the Persistence of Immune-mediated Chronic Diseases WEINBERGER, LEOR S UNIVERSITY OF CALIFORNIA SAN DIEGO Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry ZHANG, CHUN-LI UNIVERSITY OF TEXAS SW MED CTR/DALLAS Neurogenesis de novo in the adult central nervous system 2008 NIH Director’s Pioneer Award Program (DP1) RFA-RM-08-013 PI Name Institution Name Title CHEN, JAMES K STANFORD UNIVERSITY Chemical Embryology: Technologies for Manipulating and Visualizing Development DOLMETSCH, RICARDO E STANFORD UNIVERSITY Using induced pluripotent stem cells to identify the cellular phenotypes of autis EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA Cellular logic of phenotype EPSTEIN, JOSHUA M BROOKINGS INSTITUTION CENTER Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Diseases HAY, BRUCE A CALIFORNIA INSTITUTE OF TECHNOLOGY Engineering the genetics of wild mosquito populations to fight infectious disease HOCHSCHILD, ANN HARVARD MEDICAL SCHOOL A new genetic approach for studying prions and other pathogenic protein aggregate LIEBER, CHARLES M HARVARD UNIVERSITY Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials LONDON, BARRY UNIVERSITY OF PITTSBURGH In-Vivo Electrophysiology Imaging MANIATIS, THOMAS P HARVARD UNIVERSITY Use of induced pluripotent stem cells to study mechanims of familial and sporadic ODOM, TERI WANG NORTHWESTERN UNIVERSITY Reconstructing Sub-cellular Structure using Plasmonic Metamaterials PARK, HONGKUN HARVARD UNIVERSITY Nano- and Microelectronic Tools for Interrogating Neuronal Circuits and Networks REGEV, AVIV MASSACHUSETTS INST OF TECHNOLOGY BROAD INSTITUTE The temporal reconfiguration of regulatory networks: From yeast to cancer SAMUEL, ARAVINTHAN D HARVARD UNIVERSITY Biophysical approaches to complex navigational behaviors in larval Drosophila mel TAVAZOIE, SAEED F PRINCETON UNIVERSITY Towards a cognitive framework for understanding cellular behavior TING, ALICE Y MASSACHUSETTS INST OF TECHNOLOGY Enabling the study of endogenous proteins in live cells VAN OUDENAARDEN, ALEXANDER MASSACHUSETTS INST OF TECHNOLOGY Stochastic gene expression in differentiation and development 2008 NIH Director’s New Innovator Award Program (DP2) RFA-RM-08-014 PI Name Institution Name Title BRYANT, ZEV STANFORD UNIVERSITY Engineering Molecular Motors BUCKANOVICH, RONALD J THE REGENTS OF THE UNIVERSITY OF MICHIGAN Using embryonic stem cells to re-create a human tumor microenvironment to develop CARDOZO, TIMOTHY J NEW YORK UNIVERSITY SCHOOL OF MEDICINE Chemical Biology Design For Malaria CHRISTMAN, KAREN L UNIVERSITY OF CALIFORNIA, SAN DIEGO Engineering a Dynamic Extracellular Matrix Microenvironment COBB, BRIAN A CASE WESTERN RESERVE UNIVERSITY T cell Dependent Immune Responses to Carbohydrate Antigens COHN, RONALD D JOHNS HOPKINS UNIVERSITY Maintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation DUAN, XIANGFENG UNIVERSITY OF CALIFORNIA, LOS ANGELES Integrated Free-standing Nanoprobes for Neuroscience and Beyond FIELD, SETH J UNIVERSITY OF CALIFORNIA, SAN DIEGO Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology GITAI, ZEMER PRINCETON UNIVERSITY Discovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology GITLER, AARON D UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE Using yeast cells to define mechanisms of human neurodegenerative diseases GRACIAS, DAVID H JOHNS HOPKINS UNIVERSITY Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine HAYNES, CHRISTY L UNIVERSITY OF MINNESOTA Immune System-On-A-Chip For Quantitative Analysis Of Cell Interactions During All KESLER, SHELLI R STANFORD UNIVERSITY SCHOOL OF MEDICINE Assessment and Treatment of Cognitive Deficits in Breast Cancer KIRICHOK, YURIY UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO Molecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targ KUMAR, SANJAY UNIVERSITY OF CALIFORNIA, BERKELEY Cellular mechanobiology: Biophysics and therapeutics KUO, CHAY T DUKE UNIVERSITY MEDICAL CENTER Discovering pathways regulating neurogenesis and brain remodeling after injury MAHAL, LARA K UNIVERSITY OF TEXAS AT AUSTIN An integrated systems approach to deconstructing glycosylation MURPHY, COLEEN TARA PRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTE Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators NOMA, KENICHI WISTAR INSTITUTE A New Methodology to Decipher Three-Dimensional Genome Structure OHI, MELANIE DIANE VANDERBILT UNIVERSITY MEDICAL CENTER Multifaceted Approaches for Studying the Structure and Function of Spliceosomes PFENNIG, KARIN S UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL The origins and maintenance of context-dependent behavior RAMALHO-SANTOS, MIGUEL UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO Role of pluripotency in development of the germline RECK-PETERSON, SAMARA L HARVARD MEDICAL SCHOOL Cellular Control of Microtubule-Based Transport: Unraveling its Molecular Mechan SHAPIRO, ERIK YALE UNIVERSITY SCHOOL OF MEDICINE Single cell MRI of directed cell migration to stroke SHIH, WILLIAM M DANA-FARBER CANCER INSTITUTE NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes WAGERS, AMY JO JOSLIN DIABETES CENTER Aging and Rejuvenation of the hematopoietic stem cell niche WANG, JUE D BAYLOR COLLEGE OF MEDICINE The Molecular Interface of Replication Elongation and the Cellular Environment WANG, LEI SALK INSTITUTE OF BIOLOGICAL STUDIES Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans WU, JOSEPH C STANFORD UNIVERSITY SCHOOL OF MEDICINE 09: Inducing Pluripotency with MiRNAs: New Paradigm Shif in Cell Reprogramming WU, SEAN M MASSACHUSETTS GENERAL HOSPITAL Generation of functional organs via developmental chimerism ZEITLINGER, JULIA STOWERS INSTITUTE FOR MEDICAL RESEARCH Investigating Developmental Potential Based on Genome-wide Chromatin Status 2007 NIH Director's Pioneer Award Program (Re-issuance) (DP1) RFA-RM-07-005 PI Name Institution Name Title BARRETT, LISA FELDMAN Trustees of Boston College Emotions are emergent events constrained by affective and conceptual processes. BEARMAN, PETER COLUMBIA UNIV NEW YORK MORNINGSIDE Social Determinants of the Autism Epidemic BROWN, EMERY NEAL MASSACHUSETTS GENERAL HOSPITAL A Systems Neuroscience for the Study of General Anesthesia CLANDININ, THOMAS R STANFORD UNIVERSITY Dissecting the functional anatomy of the visual system: a new way forward COLLINS, JAMES J Trustees of Boston University A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms GARDEL, MARGARET LISE The University of Chicago 2007 NIH Director's Pioneer Award Program HENSCH, TAKAO Children's Hospital Corporation Dissecting Non-coding RNA Function in Critical Period Brain Development and Disorders HORWITZ, MARSHALL S University of Washington NIH Director's Pioneer Award ISMAGILOV, RUSTEM F The University of Chicago 2007 NIH Director's Pioneer Award Program JENSEN, FRANCES E Children's Hospital Corporation Understanding the Cognitive Impact of Early Life Epilepsy SCHNITZER, MARK J STANFORD UNIVERSITY Massively Parallel Brain Imaging TURRIGIANO, GINA G Brandeis University Probing the Structure of the Synapse Using Superresolution Light Microscopy 2007 NIH Director's New Innovator Award Program (DP2) RFA-RM-07-009 PI Name Institution Name Title Aagaard-Tillery, Kjersti BAYLOR COLLEGE OF MEDICINE Characterization of the Fetal Primate Epigenome and Metabolome Under In Utero Bailey, Ryan UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays Boyden, Edward MASSACHUSETTS INSTITUTE OF TECHNOLOGY Novel Tools and Principles for Precisely Controlling Brain Activity Champagne, Frances COLUMBIA UNIV NEW YORK MORNINGSIDE Epigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior Davies, Sean VANDERBILT UNIVERSITY Transformed Probiotic Bacteria for Treatment of Chronic Diseases Fernandez-Funez, Pedro UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Mechanisms of Prion Misfolding Fortune, Sarah HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) Variation in M. tuberculosis in response to host selection Garraway, Levi DANA-FARBER CANCER INSTITUTE Defining Melanoma Therapeutic Avenues by Integrative Functional Genomics Gumbo, Tawanda UNIVERSITY OF TEXAS SW MED CTR/DALLAS Efflux pump inhibitors to reduce duration of antituberculosis therapy Hacohen, Nir MASSACHUSETTS GENERAL HOSPITAL Revealing pathogen-sensing pathways using RNAi libraries Heldwein, Ekaterina TUFTS UNIVERSITY BOSTON Structural and mechanistic studies of herpesvirus entry into host cells Hochedlinger, Konrad MASSACHUSETTS GENERAL HOSPITAL Reprogramming of somatic cells by defined factors Jacobson, Kristen UNIVERSITY OF CHICAGO From Neighborhoods to Neurons and Beyond Jankowsky, Joanna CALIFORNIA INSTITUTE OF TECHNOLOGY Selective neuronal silencing to study cognitive decline in Alzheimer's disease Jasanoff, Alan MASSACHUSETTS INSTITUTE OF TECHNOLOGY Genetically-controlled MRI contrast agents for functional brain imaging Johnson, Mark BRIGHAM AND WOMEN'S HOSPITAL MicroRNA Biogenesis and the Cancer Proteome Llinas, Manuel PRINCETON UNIVERSITY Novel antimalarial strategies using metabolomic network discovery Papa, Feroz UNIVERSITY OF CALIFORNIA SAN FRANCISCO New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living Pe'Er, Dana COLUMBIA UNIV NEW YORK MORNINGSIDE Genetic variation and regulatory networks: Mechanisms and complexity Plath, Kathrin UNIVERSITY OF CALIFORNIA LOS ANGELES CHROMATIN AND EPIGENETIC INHERITANCE Rape, Michael UNIVERSITY OF CALIFORNIA BERKELEY Ubiquitin-dependent mechanisms of tissue-specific cell cycle control Rosenblatt, Jody UNIVERSITY OF UTAH Identification of signals that extrude an apoptotic cell from an epithelium Saghatelian, Alan HARVARD UNIVERSITY Discovery metabolite profiling of the prolyl peptidases Shorter, James UNIVERSITY OF PENNSYLVANIA Amyloid elimination by Hsp104 and substrate-optimized variants Sipkins, Dorothy UNIVERSITY OF CHICAGO Stem cell, tumor and bone marrow microenvironment cross-talk in vivo Spiegel, David YALE UNIVERSITY Small-Molecule Antibody Recruiting Therapeutics for Treating Human Disease Szigethy, Eva UNIVERSITY OF PITTSBURGH AT PITTSBURGH Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Ill Toomre, Derek YALE UNIVERSITY Novel TIRF microscopy for analyzing trafficking and signaling at the cell co Yang, Jing UNIVERSITY OF CALIFORNIA SAN DIEGO Epithelial-Mesenchymal Transition in Tumor Metastasis Yanik, Mehmet MASSACHUSETTS INSTITUTE OF TECHNOLOGY Development of on-chip ultra high-throughput whole-animal assay technologies NIH Director’s Pioneer Awards Program (DP1) RFA-RM-06-005 PI Name Institution Name Title BOAHEN, KWABENA STANFORD UNIVERSITY Neurogrid: Emulating a Million Neurons in the Cortex CHAKRABORTY, ARUP K. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing the Principles Governing T Lymphocyte-Mediated Autoimmunity Using an Approach at an Intersection of the Physical and Life Sciences GIERASCH, LILA M. UNIVERSITY OF MASSACHUSETTS AMHERST NIH Director’s Pioneer Award Application HEALD, REBECCA W. UNIVERSITY OF CALIFORNIA BERKELEY NIH Director’s Pioneer Award Application KIRKEGAARD, KARLA A. STANFORD UNIVERSITY Dominant Drug Targets in RNA Viruses KODADEK, THOMAS UNIVERSITY OF TEXAS SW MED CTR/DALLAS Novel Chemistry to Monitor and Manipulate the Immune System LEE, CHENG C. UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Reversible Suspended Animation of Non-hibernating Mammals NUDLER, EVGENY NEW YORK UNIVERSITY SCHOOL OF MEDICINE New Approaches to Fight Infection PIELAK, GARY J. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL In-Cell NMR of Disease-Related Proteins RELMAN, DAVID A. STANFORD UNIVERSITY NIH Director's Pioneer Award Application SEGAL, ROSALIND A. DANA-FARBER CANCER INSTITUTE An extended view of self: human indigenous microbial communities in health and disease SHERLEY, JAMES L. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Pioneering Human Adult Stem Cell Discovery and Cellular Medicine XIA, YOUNAN UNIVERSITY OF WASHINGTON Put Nanostructures to Work for Reading and Controlling Cell Behavior NIH Director’s Pioneer Awards Program (Re-issuance) (DP1) NOT-OD-05-021 PI Name Institution Name Title CHANDLER, VICKI L UNIVERSITY OF ARIZONA NIH Director’s Pioneer Award CLINE, HOLLIS T COLD SPRING HARBOR LABORATORY NIH Director’s Pioneer Award COSMIDES, LEDA UNIVERSITY OF CALIFORNIA SANTA BARBARA NIH Director’s Pioneer Award DE LANGE, TITIA ROCKEFELLER UNIVERSITY NIH Director’s Pioneer Award DEISSEROTH, KARL A STANFORD UNIVERSITY NIH Director’s Pioneer Award HARBURY, PEHR A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director’s Pioneer Award JARVIS, ERICH D DUKE UNIVERSITY MEDICAL CENTER NIH Director’s Pioneer Award RANDO, THOMAS A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director’s Pioneer Award SMITH, DEREK J UNIVERSITY OF CAMBRIDGE NIH Director’s Pioneer Award TONONI, GIULIO UNIVERSITY OF WISCONSIN – MADISON MEDICAL SCHOOL NIH Director’s Pioneer Award WATERMAN-STORER, CLARE M SCRIPPS RESEARCH INSTITUTE NIH Director’s Pioneer Award WOLFE, NATHAN JOHNS HOPKINS UNIVERSITY NIH Director’s Pioneer Award YUAN, JUNYING HARVARD MEDICAL SCHOOL NIH Director’s Pioneer Award NIH Director’s Pioneer Award (DP1) RFA-RM-04-500 PI Name Institution Name Title ABBOTT, LARRY F. BRANDEIS UNIVERSITY NIH Director’s Pioneer Award DALEY, GEORGE Q CHILDREN'S HOSPITAL (BOSTON) NIH Director’s Pioneer Award HELLINGA, HOMME W. DUKE UNIVERSITY NIH Director’s Pioneer Award MCCUNE, JOSEPH M J. DAVID GLADSTONE INSTITUTES NIH Director’s Pioneer Award MCKNIGHT, STEVEN L UNIVERSITY OF TEXAS SW MED CTR/DALLAS NIH Director’s Pioneer Award MIRKIN, CHAD A NORTHWESTERN UNIVERSITY NIH Director’s Pioneer Award PHILLIPS, ROB CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Director’s Pioneer Award QUAKE, STEPHEN R CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Director’s Pioneer Award XIE, SUNNEY HARVARD UNIVERSITY NIH Director’s Pioneer Award Up to Top

This page last reviewed: October 5, 2009

DPCPSI Home | NIH Office of the Director | Contact Us | Site Map | Privacy Policy | Accessibility | FOIA | Disclaimers

Division of Program Coordination, Planning, and Strategic Initiatives • National Institutes of Health • Bethesda, Maryland 20892