Transformative R01 Program

Overview

Transformative Research Projects Program

The Roadmap Transformative Research Projects Program (R01) was specifically created under the NIH Roadmap for Medical Research to support exceptionally innovative, high risk, original and/or unconventional research projects that have the potential to create or overturn fundamental paradigms. These projects tend to be inherently risky, but if successful can profoundly impact a broad area of biomedical research.

As compared to the NIH Director’s Pioneer and New Innovator Programs, the primary emphasis of the Roadmap Transformative Research Projects Program is on creative ideas—projects that have the potential to transform a field of science and to provide adequate support for the work—rather than creative individuals who have proven themselves to be innovative researchers and to provide them with funds to go in a new pioneering direction.

To facilitate submission and review of the most bold, creative and high impact proposals, the Roadmap Transformative Research Projects Program is also piloting novel approaches to peer review and program management. The high degree of risk inherent to truly transformative research is expected and welcomed in proposals under the Roadmap Transformative Research Program. Transformative projects in any area of NIH interest are encouraged and are considered responsive to T-R01 funding opportunities.

Awardees under the Roadmap Transformative Research Projects Program will be expected to participate in an annual symposium on the NIH campus. This symposium will allow awardees to share their ideas, progress, and experience with each other, the research community, and NIH staff.

Inquiries

For more information about the Transformative R01 program see the 2010 Frequently Asked Questions, or e-mail your questions to T_R01@mail.nih.gov.

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